R. Loch Macdonald
Head Neurosurgery
Division of Neurosurgery, St. Michael's Hospital


Research Interests: Subject Area Themes: Subarachnoid hemorrhage, cerebral vasospasm, cerebral blood flow and metabolism, stroke, cerebral aneurysms, cerebrovascular malformations, chronic subdural hematoma, intracerebral hemorrhage

Bio Brief

Dr. Macdonald's major research interests are in the field of aneurismal subarachnoid hemorrhage and cerebral vasospasm. We are investigating causes of delayed neurological deterioration after subarachnoid hemorrhage using animal models and testing hippocampal electrophysiology and function, animal behavior, learning and memory and changes in gene expression and function. We also are studying mechanisms of large artery vasospasm after aneurismal subarachnoid hemorrhage and effects of intracerebral and subdural hemorrhage on the brain. All of this work is laboratory-based as well as clinical with clinical trials and patient-based studies conducted testing similar hypotheses.

Other Highlights:

Revolutionizing Hospital Care With Artificial Intelligence: Dr. Muhammad Mamdani

Zoya Retiwalla | TRP | December 6, 2019 "There are products that can have a real impact but then whether the product has an impact on the masses and brings revenue are important considerations. Plugs can be pulled if the impact and returns aren’t strong," Dr. Muhammad...

TRP student & alumna collaborate on Doctor’s Note, Toronto Star

By DR. MICHELLE JACOBSON, KATIE TUCKER | University of Toronto Wed., March 28, 2018 | Toronto Star   Hysterectomy is the most common major gynecologic procedure done in Canada, with more than 100 performed daily. This procedure involves the removal of all or part...

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