Mingyao Liu
Director of Research
Institute of Medical Science, University of Toronto


Research Interests: Subject Area Themes: signal transduction, inflammation, lung transplantation, acute lung injury, drug discovery, cell death, nano-drug delivery, cell motility, tumourigenesis

Bio Brief

We are focusing on the ischemia-reperfusion induced lung injury in lung transplantation, and the cellular and molecular mechanisms of acute lung injury. We have developed nano-particular based drug delivery systems for hydrophobic drugs/chemicals. We are developing a high throughput drug screening for ischemia-reperfusion induced lung injury. Another major research interest is the role of adaptor proteins in signal transduction. We have cloned an adaptor protein, XB130 (AFAP1L2), which can couple protein tyrosine kinase to the PI3K pathway in cells. We have generated xb130 knockout mice through collaboration. We are exploring the role of XB130/PI3K/Akt pathway in lung tissue injury/repair and tumourigenesis.

Other Highlights:

Disrupting Change: The TRP Disruptors and their Ride to Conquer Cancer

Written By: Craig Madho, MHSc Translational Research Candidate “Wait wait wait...before everyone leaves class, I have a question.” It was 7 PM - we had just finished class and were getting ready to leave for the evening, but we had just started the second semester of...

The Brewing Fight

Gabriella Chan for the TRP, November 2020 As we approach ten months of living, working, and studying in our homes, isolated from friends and family and facing ever-increasing numbers of cases, deaths, and further isolation during the winter months, one can be forgiven...

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