Dr. Joel C. Watts

Assistant Professor, Biochemistry, University of Toronto

Protein misfolding is at the root of many neurodegenerative diseases of ageing, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Creutzfeldt-Jakob disease (CJD). These are diseases of protein conformation: the misfolding and subsequent aggregation of proteins or peptides into β-sheet-enriched forms initiates a cascade of events that ultimately leads to neurological dysfunction and death of neurons or glial cells in the brain. Dr. Watts' lab focuses on understanding the molecular details of protein aggregation with an emphasis on designing accurate animal models of protein misfolding diseases.