"My research is currently focused on understanding the pathogenesis of common human cardiovascular diseases such as atherosclerosis and heart valve disease, especially calcific aortic stenosis. The work is now focused on utilizing the expertise in the investigation of experimental models of human disease to review the vast and dynamic literature in these conditions. The purpose of these in depth reviews is to develop state of the art teaching material to be used by graduate and undergraduate students, medical students and physicians to transfer up to date knowledge to them. The reviews sift through the literature in a critical fashion to identify validated concepts and to look for new trends emerging in understanding pathogenesis. The focus is primarily on understanding the cell and molecular biology of the disease conditions and the influence of physical forces on regulating these processes. The emphasis is on the cells in the normal and diseased tissue and how these cells maintain normal physiologic conditions and then undergo transformations to regulate the pathological states that are found in disease."
Professor Avrum I. Gotlieb, founding Chair of the Department of Laboratory Medicine and Pathobiology (LMP), Faculty of Medicine, University of Toronto, (1997-2008) obtained his BSc in Psychology and Physiology, with first class honors, (1967) and his MDCM (1971) from McGill University. He continued his training in medicine and anatomic pathology at the teaching hospitals of McGill University. He obtained his Fellowship from the Royal College of Physicians and Surgeons of Canada in Anatomic Pathology (1975) and certification from the American Board of Pathology (1976). He pursued research training in cell biology in the Department of Biology, University of California San Diego with Professor SJ Singer, supported by a Medical Research Council Fellowship. He is currently Interim Vice Dean, Graduate and Life Sciences Education and Senior Academic Advisor to the Dean, Faculty of Medicine, University of Toronto
Professor Gotlieb's research interests include atherosclerosis and valvular heart disease. He has published on blood vessel repair especially on the role of the cytoskeleton in endothelial repair and his research studied how heart valve cells repair valves after they have been injured. He has published over 100 peer reviewed papers, and 35 reviews and book chapters. He edited three books, including the comprehensive textbook Cardiovascular Pathology, edited with colleagues MD Silver, University of Toronto, and F Schoen, Harvard Medical School. He has received peer reviewed funding from the Heart and Stroke Foundation of Ontario and the Medical Research Council (now Canadian Institutes of Health Research), CIHR.
Professor Gotlieb is the past co-Editor of Cardiovascular Pathology, a journal of the Society for Cardiovascular Pathology dedicated to basic, clinical, and applied cardiovascular science published by Elsevier. He serves on the Editorial Board of The American Journal of Pathology (AJP) and Laboratory Investigation.
Professor Gotlieb is a former President of the American Society for Investigative Pathology (ASIP) and past President of the Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology (CSATVB) and the Society for Cardiovascular Pathology (SCVP). He was a member of the Board of the Federation of American Societies of Experimental Biology (FASEB) and served as FASEB Vice-President for Science Policy. He is an elected Fellow of the Canadian Academy of Health Sciences and was honoured by SCVP with the Distinguished Achievement Award and by ASIP with the Robbins Distinguished Educator Award, and by the Association of Pathology Chairs with their Distinguished Service Award. He has presented career talks at several national and international scientific meetings and venues.