Details for Seminar Discussants
The TRP Foundations in Translational Research course (MSc1000) is central to providing students with an overview of the health innovation landscape that is core to the Translational Research Master’s (visit TRP.utoronto.ca for more information about the program) and asks one fundamental question: how can we collaborate to expedite positive impacts on health and care?
Throughout the term we cover a range of topics including: the politics of funding research; identifying interesting targets, problems and projects; study design and expediting clinical trials; understanding intellectual property rights; commercialization strategies and regulatory frameworks; policy and evaluation of interventions; and education and implementation science.
Your experience and insights help bring diversity of opinions, depth of experience and range of domain expertise to conversations on the complex processes of translating discoveries into interventions and are key to raising interesting and relevant issues related to the problems and opportunities for innovation in health science.
The seminar is two hours and is intended to encourage exchange, critical thinking and community building. During the first hour, students will facilitate a discussion among all the discussants and the class about Translational challenges and opportunities. During the second hour, each of the discussants will meet with two smaller groups of students to continue the conversation. After the smaller breakout sessions the class will reunite and the guests will be asked to share their insights to the group. No PowerPoint or preparations are needed on your part.
The seminars will take place at the TRP, in the main Auditorium of the Old Administration Building (OA) at 263 McCaul St. The entrance to the building is down a long walkway off the east side of McCaul Street, south of College (behind the Dalla Lana building). Click to see map.
If you are able to attend us please confirm by simply responding to the email that was sent to you that includes the date and time of the seminar. If you are unable to make this date, but would still like to contribute, please indicate which of the seminar themes below you would be interested in attending and fits your schedule.
This is will be our third iteration of this course and we have learned that the Discussants are central to the learning experience. Your participation helps students gain insight and an appreciation of the diverse health science landscape, so we are very much looking forward to having you join the conversation.
WEEK 3: SEPTEMBER 26
Translational Research, Translational Medicine, & Knowledge Translation. Could this get more confusing?
- Research to Practice
- Practice to research
- Bench to bookshelf
- Bench to bedside
- Cell to Society
- Womb to Tomb
WEEK 4: OCTOBER 3
Human Centric Design
- What is the role of the patient in health care?
- How do wants and needs change based on point of view?
- The Quantified Self
WEEK 5: OCTOBER 10
Pathways to Impact
- What is translational impact and how do you measure it?
- Endpoints vs Outcomes
- Kinds of Outcomes
Translational Researcher Tools: Overview
- Evidence-based Medicine
- Intellectual Property: Patents & Licenses
- Clinical Trials
- Implementation Science
- Research Ethics
WEEK 7: OCTOBER 24
Translational Researcher Tools: Intellectual Property
- What is Intellectual Property (IP)?
- Why is IP important to translation
- In which stages of Translation does IP play a significant role?
WEEK 8: OCTOBER 31
Translational Research Tools: Funding
- Public funding
- Private funding
- Identifying sources
- How has the funding for health science innovation changed?
WEEK 9: NOVEMBER 7
Translational Researcher Tools: Regulatory
- Why is it important to understand regulatory procedure before starting a project?
- Endpoints vs Outcomes
- Pre-Investigative Device Exemptions
- Risk Management
WEEK 10: NOVEMBER 14
Translational Tool: Pathways to Market
- Working within universities and hospitals vs branching out on your own.
Translational Research Tools: Implementation Science
PRESENTATION & NOTES
- Frameworks & Methods:
- Do evidence-based programs work?
- How does implementation work in the real-world: Stories from the front lines.
WEEK 12: NOVEMBER 28
Translational Research Tools: Policy & Evidence-based Medicine
- Why change policy?
- How can you effect policy change?
- Approaches & challenges to change
Reflection & Review
- What have we leaned so far?
- 2 year Capstone Presentationsv
WEEK 14: JANUARY 9
Overview: The Valley(s) of Death
- T1 Research to Discovery
- T2: Lab to Clinic
- T3: Clinic to Practice
- T4: Practice to Popualtion
- T5: Population to Policy
WEEK 15: JANUARY 16
T0: Politics to Preclinical Research
- Funding Research
- Showing Impact
- Health economics
- Epidemiology and Population Health
WEEK 16: JANUARY 23
T4/5: Translation to Populations/Policy
- Changing Protocols/standard of care & SOP’s
- Marketing and Education Behavioural change
- Adoption & Adherence
WEEK 17: JANUARY 30
T3: Translation to Practice (clinical Implementation)
- Adoption into clinical practice
- Teaching Physicians updated approaches
- Tools that can be used to effect change
WEEK 18: FEBRUARY 6
T2/T3: Translation to Patients (Clinical Research)
- Influencing change in clinical practice
- Reverse Translation: How has clinical experience influenced the direction of research and your research clinical practice?
WEEK 19: FEBRUARY 13
Pharmaceuticals: Clinical Trials
- Overview of clinical trial phases
- What is the role of regulatory agencies?
- High throughput screening
- Post market-analysis
WEEK 20: FEBRUARY 27
Devices: Regulation and Clinical Trials
- Device classifications
- Design Control
- Pathway to Market
- What are the challenges of bring a device to market?
WEEK 21: MARCH 6
T2: Translation to Humans
- What are the barriers for getting bench discoveries into clinics and clinical trials?
WEEK 22: MARCH 13
T1: Basic Discovery Science
- Research vs Discovery
- How is translational research different from discovery research?
- Identifying targets
- Mobilization & Application
- Publication & Innovation
- Peer Review
- Grants and Funding
- Employment and Academic Careers
WEEK 23: MARCH 20
- Field of Research: How to expedite Translation?
- The future of translation
- What constitutes a scientific discipline?
- Is the Mobilization of Science a disciplinary cannon? Or is it a vocation?
WEEK 24: MARCH 27
- Building a local Community
- International Impact
- Establishing a core ‘Profession’
- Researching the field
WEEK 25: APRIL 3
Reflections and Wrap-up
- What have we learned?
- 2 year Capstone Presentations