September 13, 2017

TRP Foundations in Translational Research

Details for Seminar Discussants

 

The TRP Foundations in Translational Research course (MSc1000) is central to providing students with an overview of the health innovation landscape that is core to the Translational Research Master’s (visit TRP.utoronto.ca for more information about the program) and asks one fundamental question: how can we collaborate to expedite positive impacts on health and care?

Throughout the term we cover a range of topics including: the politics of funding research; identifying interesting targets, problems and projects; study design and expediting clinical trials; understanding intellectual property rights; commercialization strategies and regulatory frameworks; policy and evaluation of interventions; and education and implementation science.

Your experience and insights help bring diversity of opinions, depth of experience and range of domain expertise to conversations on the complex processes of translating discoveries into interventions and are key to raising interesting and relevant issues related to the problems and opportunities for innovation in health science.

The seminar is two hours and is intended to encourage exchange, critical thinking and community building. During the first hour, students will facilitate a discussion among all the discussants and the class about Translational challenges and opportunities. During the second hour, each of the discussants will meet with two smaller groups of students to continue the conversation.  After the smaller breakout sessions the class will reunite and the guests will be asked to share their insights to the group.  No PowerPoint or preparations are needed on your part.  

The seminars will take place at the TRP, in the main Auditorium of the Old Administration Building (OA) at 263 McCaul St. The entrance to the building is down a long walkway off the east side of McCaul Street, south of College (behind the Dalla Lana building). Click to see map.

If you are able to attend us please confirm by simply responding to the email that was sent to you that includes the date and time of the seminar. If you are unable to make this date, but would still like to contribute, please indicate which of the  seminar themes below you would be interested in attending and fits your schedule.

This is will be our third iteration of this course and we have learned that the Discussants are central to the learning experience.  Your participation helps students gain insight and an appreciation of the diverse health science landscape, so we are very much looking forward to having you join the conversation.

Seminar Schedule

WEEK 3: SEPTEMBER 26

TOPIC

Translational Research, Translational Medicine, & Knowledge Translation. Could this get more confusing?

PRESENTATION & NOTES

  • Research to Practice
  • Practice to research
  • Bench to bookshelf
  • Bench to bedside
  • Cell to Society
  • Womb to Tomb

WEEK 4: OCTOBER 3

TOPIC

Human Centric Design

PRESENTATION & NOTES

  • What is the role of the patient in health care?
  • How do wants and needs change based on point of view?
  • The Quantified Self

WEEK 5: OCTOBER 10

TOPIC

Pathways to Impact

PRESENTATION & NOTES

  • What is translational impact and how do you measure it?
  • Endpoints vs Outcomes
  • Kinds of Outcomes
WEEK 6: OCTOBER 17

TOPIC

Translational Researcher Tools: Overview

PRESENTATION & NOTES

  • Evidence-based Medicine
  • Intellectual Property: Patents & Licenses
  • Funding
  • Regulatory
  • Clinical Trials
  • Commercialization
  • Implementation Science
  • Policy
  •  Research Ethics
 

WEEK 7: OCTOBER 24

TOPIC

Translational Researcher Tools: Intellectual Property

PRESENTATION & NOTES

  • What is Intellectual Property (IP)?
  • Why is IP important to translation
  • In which stages of Translation does IP play a significant role?

 WEEK 8: OCTOBER 31

TOPIC

Translational Research Tools: Funding

PRESENTATION & NOTES

  • Public funding
  • Private funding
  • Identifying sources
  • How has the funding for health science innovation changed?

WEEK 9: NOVEMBER 7

TOPIC

Translational Researcher Tools: Regulatory

PRESENTATION & NOTES

  • Why is it important to understand regulatory procedure before starting a project?
  • Endpoints vs Outcomes
  • Jurisdictions
  • Pre-Investigative Device Exemptions
  • Risk Management

WEEK 10: NOVEMBER 14

TOPIC

Translational Tool: Pathways to Market

PRESENTATION & NOTES

  • Licensing
  • Commercialization
  • Partnerships
  • Ecosystems
  • Working within universities and hospitals vs branching out on your own.
 
WEEK 11: NOVEMBER 21

TOPIC

Translational Research Tools: Implementation Science

 PRESENTATION & NOTES

  • Frameworks & Methods:
  • Do evidence-based programs work?
  • How does implementation work in the real-world: Stories from the front lines.

WEEK 12: NOVEMBER 28

TOPIC

Translational Research Tools: Policy & Evidence-based Medicine

PRESENTATION & NOTES

  • Why change policy?
  • How can you effect policy change?
  • Approaches & challenges to change
 
WEEK 13: DECEMBER 5

TOPIC

Reflection & Review

PRESENTATION & NOTES

  • What have we leaned so far?
  • 2 year Capstone Presentationsv

WEEK 14: JANUARY 9

TOPIC

Overview: The Valley(s) of Death

PRESENTATION & NOTES

  • T1 Research to Discovery
  • T2: Lab to Clinic
  • T3: Clinic to Practice
  • T4: Practice to Popualtion
  • T5: Population to Policy

WEEK 15: JANUARY 16

TOPIC

T0: Politics to Preclinical Research

PRESENTATION & NOTES

  • Funding Research
  • Showing Impact
  • Health economics
  • Epidemiology and Population Health

WEEK 16: JANUARY 23

TOPIC

T4/5: Translation to Populations/Policy

PRESENTATION & NOTES

  • Changing Protocols/standard of care & SOP’s
  • Marketing and Education Behavioural change
  • Adoption & Adherence

WEEK 17: JANUARY 30

TOPIC

T3: Translation to Practice (clinical Implementation)

PRESENTATION & NOTES

  • Adoption into clinical practice
  • Teaching Physicians updated approaches
  • Tools that can be used to effect change

WEEK 18: FEBRUARY 6

TOPIC

T2/T3: Translation to Patients (Clinical Research)

PRESENTATION & NOTES

  • Influencing change in clinical practice
  • Reverse Translation: How has clinical experience influenced the direction of research and your research clinical practice?

WEEK 19: FEBRUARY 13

TOPIC

Pharmaceuticals: Clinical Trials

PRESENTATION & NOTES

  • Overview of clinical trial phases
  • What is the role of regulatory agencies?
  • High throughput screening
  • Post market-analysis

WEEK 20: FEBRUARY 27

TOPIC

Devices: Regulation and Clinical Trials

PRESENTATION & NOTES

  • Device classifications
  • Design Control
  • Pathway to Market
  • What are the challenges of bring a device to market?

WEEK 21: MARCH 6

TOPIC

T2: Translation to Humans

PRESENTATION & NOTES

  • What are the barriers for getting bench discoveries into clinics and clinical trials?

WEEK 22: MARCH 13

TOPIC

T1: Basic Discovery Science

PRESENTATION & NOTES

  • Research vs Discovery
  • How is translational research different from discovery research?
  • Identifying targets
  • Mobilization & Application
  • Publication & Innovation
  • Peer Review
  • Grants and Funding
  • Employment and Academic Careers

WEEK 23: MARCH 20

TOPIC

Translational Science

PRESENTATION & NOTES

  • Field of Research: How to expedite Translation?
  • The future of translation
  • What constitutes a scientific discipline?
  • Is the Mobilization of Science a disciplinary cannon? Or is it a vocation?

WEEK 24: MARCH 27

TOPIC

Translational Frontiers

PRESENTATION & NOTES

  • Building a local Community
  • International Impact
  • Establishing a core ‘Profession’
  • Researching the field

WEEK 25: APRIL 3

TOPIC

Reflections and Wrap-up

PRESENTATION & NOTES

  • What have we learned?
  • 2 year Capstone Presentations