Dr. R. Loch Macdonald, MD, PhD, FRCSC, FACS
Head Neurosurgery, Scientist, Professor
Head, Division of Neurosurgery, St. Michael's Hospital, Keenan Endowed Chair in Surgery, St. Michael's Hospital , Adjunct Scientist, Research Institute, Hospital for Sick Children, Member, Institute of Medical Science, University of Toronto , Scientist, Keenan Research Center, St. Michael's Hospital , Scientist, Li Ka Shing Knowledge Institute, St. Michael's Hospital , Professor of Surgery, Faculty of Medicine, University of Toronto
Dr. Macdonald's major research interests are in the field of aneurismal subarachnoid hemorrhage and cerebral vasospasm. We are investigating causes of delayed neurological deterioration after subarachnoid hemorrhage using animal models and testing hippocampal electrophysiology and function, animal behavior, learning and memory and changes in gene expression and function. We also are studying mechanisms of large artery vasospasm after aneurismal subarachnoid hemorrhage and effects of intracerebral and subdural hemorrhage on the brain. All of this work is laboratory-based as well as clinical with clinical trials and patient-based studies conducted testing similar hypotheses.