1) The role of telomere maintenance in paediatric neuronal tumours. In collaboration with other laboratories in the Brain Tumour Research Centre (BTRC) and the Research Institute, Dr. Tabori’s laboratory is examining the role of telomerase inhibition in glioma and neuroblastoma stem cells. 2) Uncovering the mechanisms that govern the spontaneous growth arrest of paediatric low grade gliomas. Dr. Tabori’s laboratory is investigating the pathways that control this unique phenomenon. Understanding the phenotype of these fascinating tumours will enable us to potentially reverse the high-grade tumours into treatable ones. 3) The role of radioresistance and sensitivity in determining survival and long-term radiation side effects in children with brain tumours. Using novel techniques to measure radiation response in tumour and blood cells from patients and in collaboration with the SickKids neuropsychological team, Dr. Tabori hopes to determine which tumours will be resistant to radiation therapy and which patients are specifically sensitive to radiation and will need dose modifications to avoid the severe long-term neuro-cognitive effects. 4) The genetic profile of paediatric gliomas. Dr. Tabori’s laboratory is investigating the role of several tumour suppressor genes, in which germline mutations predispose these children to early onset brain tumours, in brain tumour initiation and progression.
Haematology/Oncology, The Hospital for Sick Children
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