Research Area Themes: Acute respiratory distress syndrome, ventilator-induced lung injury, mechanotransduction, organ failure, mechanical ventilation, differential gene expression
Dr. Claudia dos Santos' major research interest is acute lung injury. This can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. Her lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals, who are at higher risk for developing lung injury, diagnose, treat and monitor improvement from injury. To accomplish their goals, they have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. They exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. They are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions her lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.