MDCM, FRCPC, Professor

Cardiovascular Disease Translator

Brief Bio:

Avrum studies the cellular and molecular pathogenesis of common human cardiovascular diseases. He synthesizes knowledge through in-depth reviews of the vast and dynamic literature. To disseminate this knowledge, he develops state of the art teaching materials to educate undergraduate and graduate students, as well as physicians. Avrum is the founding Chair of the Department of Laboratory Medicine and Pathobiology within the Faculty of Medicine at U of T (1997-2008). He is an award-winning educator. His latest book on career development and mentorship is titled, “Planning a Career in Biomedical and Life Sciences: Learn to Navigate a Tough Research Culture by Harnessing the Power of Career Building” (2nd edition, Elsevier 2018). Students learn to identify effective supervisors and mentors and gain insight into self-reflection, resilience, and overcoming failures. At the TRP, Avrum is our Senior Program Advisor.

Research Interests:

"My research is currently focused on understanding the pathogenesis of common human cardiovascular diseases such as atherosclerosis and heart valve disease, especially calcific aortic stenosis. The work is now focused on utilizing the expertise in the investigation of experimental models of human disease to review the vast and dynamic literature in these conditions. The purpose of these in depth reviews is to develop state of the art teaching material to be used by graduate and undergraduate students, medical students and physicians to transfer up to date knowledge to them. The reviews sift through the literature in a critical fashion to identify validated concepts and to look for new trends emerging in understanding pathogenesis. The focus is primarily on understanding the cell and molecular biology of the disease conditions and the influence of physical forces on regulating these processes. The emphasis is on the cells in the normal and diseased tissue and how these cells maintain normal physiologic conditions and then undergo transformations to regulate the pathological states that are found in disease." </P></em>


Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto



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 - Hillary Chan, 2015 Cohort