Edyta

Profile

Salutations

Ms.

Last Name

Marcon

First Name

Edyta

Credentials

PhD

Institutional Affiliations

University of Toronto, Donnelly Centre

 

Research Interests

Research Focus

Regulation of Gene Expression

 

Education

Undergraduate

York University; Biology

Graduate

York University; Genetics

Other

Postdoctoral; Donnelly Centre; Epigenetics, Proteomics

Capstone

Project Title

TBA

Publications

Publications Journal Articles ·      Gorelik, M., Orlicky, S., Sartori, M.A., Tang, X., Marcon, E., Kurinov, I., Greenblatt, J.F., Tyers, M., Moffat, J., Sicheri, F., Sidhu, S.S. Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target Cul1 binding site on the Skp1-interface. Proc Natl Acad Sci USA 113(13):3527-32 (2016). ·      Zhong, N., Loppnau, P., Seitova, A., Ravichandran, M., Fenner, M., Jain, H., Bhattacharya, A., Hutchinson, A., Paduch, M., Lu, V., Olszewski, M., Kossiakoff, A.A., Dowdell, E., Koide, A., Koide, S., Huang, H., Nadeem, V., Sidhu, S.S., Greenblatt, J.F., Marcon, E., Arrowsmith, C.H., Edwards, A.M., Graslund, S.  Optimizing production of antigens and fabs in the context of generating recombinant antibodies to human proteins. PLOSone Oct 5 DOI: 10.1371/journal.pone.0139695 (2015). ·      Marcon, E., Jain, H., Bhattacharya, A., Guo, H., Phanse, S., Pu, S., Byram, G., Collins, B.C., Dowdell, E., Fenner, M., Guo, X., Hutchinson, A., Kennedy, J.J., Krastins, B., Larsen, B., Lin, Z., Lopez, M.F., Loppnau, P., Miersch, S., Nguyen, T., Olsen, J.B., Paduch, M., Ravichandran, M., Seitova, A., Vadali, G., Vogelsang, M.S., Whiteaker, J.R., Zhong, G., Zhong, N., Zhao, L., Aebersold, R., Arrowsmith, C.H., Emili, A., Frappier, L., Gingras, A.C., Gstaiger, M., Paulovich, A.G., Koide, S., Kossiakoff, A.A., Sidhu, S.S., Wodak, S.J., Graslund, S., Greenblatt, J.F., Edwards, A.M. A method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nature Methods 12(8):725-31 (2015). ·      Pu, S., Vlasblom, J., Turinsky, A., Marcon, E., Phanse, S., Trimble, S.S., Olsen, J., Greenblatt, J., Emili, A., Wodak, S.J. Extracting high confidence protein interactions from affinity purification data: At the crossroads. J Proteomics 118, 63-80 (2015). ·      Ni, Z., Xu, C., Guo, X., Hunter, G.O., Kuznetsova, O.V., Tempel. W., Marcon, E., Zhong, G., Guo, H., Kuo, W.H., Li, J., Young, P., Olsen, J.B., Wan. C., Loppnau, P., El Bakkouri, M., Senisterra, G.A., He, H., Huang, H., Sidhu, S.S., Emili, A., Murphy, S., Mosley, A.L, Arrowsmith, C.H., Min, J., Greenblatt, J.F. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat Struct Mol Biol 21, 686-695 (2014). ·      Marcon, E., Ni, Z., Pu, S., Turinsky, A.L., Trimble, S.S., Olsen, J.B., Silverman-Gavrila, R., Silverman-Gavrila, L., Phanse, S., Guo, H., Zhong, G., Guo, X., Young, P., Bailey, S., Roudeva, D., Zhao, D., Hewel, J., Li, J., Graslund, S., Paduch, M., Kossiakoff, A.A., Lupien, M., Emili, A., Wodak, S.J., Greenblatt, F.F. Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. Cell Rep 8, 297-310 (2014). ·      Marcon, E., Smiley, S., Turinsky, A.L., Greenblatt, J. Book Chapter. Networks of Histone Demethylases and their relevance to the regulation of chromatin structure and dynamics. Book Chapter. Springer Press. Systems Analysis of Chromatin-Related Protein Complexes in Cancer. Springer (2014). ·      Paladino, P., Marcon, E., Greenblatt, J. & Frappier, L. Identification of herpesvirus proteins that contribute to G1/S arrest. J Virol 88, 4480-4492 (2014). ·      James, L.I., Barsyte-Lovejoy, D., Zhong, N., Krichevsky, L., Korboukh, V.K., Herold, J.M., MacNevin, C.J., Norris, J.L., Sagum, C.A., Tempel, W., Marcon, E., Guo, H., Gao, C., Huang, X.P., Duan, S., Emili, A., Greenblatt, J.F., Kireev, D.B., Jin, J., Janzen, W.P., Brown, P.J., Bedford, M.T., Arrowsmith, C.H., Frye, S.V. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol 9, 184-191 (2013). ·     Ni, Z., Olsen, B.J., Guo, X., Zhong, G., Ruan, E.E., Marcon, E., Young, P., Guo, H., Li, J., Moffat, J., Emili, A., Greenblatt, J.F. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription 2, 237-242 (2011). ·      Refolio, E., Cavero, S., Marcon, E., Freire, R. & San-Segundo, P.A. The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates. J Cell Sci 124, 2488-2500 (2011). ·      Mak, A.B., Ni, Z., Hewel, J.A., Chen, G.I., Zhong, G., Karamboulas, K., Blakely, K., Smiley, S., Marcon, E., Roudeva, D., Li, J., Olsen, J.B., Wan, C., Punna, T., Isserlin, R., Chetyrkin, S., Gingras, A.C., Emili, A., Greenblatt, J.F., Moffat, J.  A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics 9, 811-823 (2011). ·      Bahadorani, S., Bahadorani, P., Marcon, E., Walker, D.W. & Hilliker, A.J. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Dis Model Mech 3, 84-91 (2010). ·      Wang, X., Chinnam, M., Wang, J., Wang, Y., Zhang, X., Marcon, E., Moens, P., Goodrich, D.W. Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. Mol Cell Biol 29, 2794-2803 (2009). ·      Marcon, E. Hendrik Peter Bernelot Moens (1931-2008). Genome 51, 1063-1067 (2008). ·      Sasaki, T., Marcon, E., McQuire, T., Arai, Y., Moens, P.B., Okada, H. Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis. J Cell Biol 182, 449-458 (2008). ·      Marcon, E., Babak, T., Chua, G., Hughes, T., Moens, P.B. miRNA and piRNA localization in the male mammalian meiotic nucleus. Chromosome Res 16, 243-260 (2008). ·      Moens, P.B., Marcon, E., Shore, J.S., Kochakpour, N., Spyropoulos, B. Initiation and resolution of interhomolog connections: crossover and non-crossover sites along mouse synaptonemal complexes. J Cell Sci 120, 1017-1027 (2007). ·      McCracken, S., Longman, D., Marcon, E., Moens, P., Downey, M., Nickerson, J.A, Jessberger, R., Wilder, A., Caceres, J.F., Emili, A., Blencowe, B.J. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. J Biol Chem 280, 42227-42236 (2005). ·      Marcon, E., Moens, P.B. The evolution of meiosis: recruitment and modification of somatic DNA-repair proteins. Bioessays 27, 795-808 (2005). ·      Kolas, N.K., Marcon, E., Crackower, M.A., Hoog, C., Penninger, J.M, Spyropoulos, B., Moens, P.B. Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility. Chromosoma 114, 92-102 (2005). ·      Kolas, N.K., Yuan, L., Hoog, C., Heng, H.H., Marcon, E., Moens, P.B. Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment. Cytogenet Genome Res 105, 182-188 (2004). ·      Marcon, E., Moens, P. MLH1p and MLH3p localize to precociously induced chiasmata of okadaic-acid-treated mouse spermatocytes. Genetics 165, 2283-2287 (2003). ·      Moens, P.B., Kolas, N.K., Tarsounas, M., Marcon, E., Cohen, P., Spyropoulos, B. The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination. J Cell Sci 115, 1611-1622 (2002). Book Chapters Marcon, E., Smiley, S., Turinsky, A.L., Greenblatt, J. Book Chapter. Networks of Histone Demethylases and their relevance to the regulation of chromatin structure and dynamics. Book Chapter. Springer Press. Systems Analysis of Chromatin-Related Protein Complexes in Cancer. Springer (2014).